The Lockheed U-2, nicknamed "Dragon Lady", is an American single-jet engine, high altitude reconnaissance aircraft operated by the United States Air Force and previously flown by the CIA. It provides day and night, high-altitude (70,000 feet, 21,300 meters), all-weather intelligence gathering.

The documentary follows the acclaimed actor and humanitarian Gary Sinise as he prepares and travels to the edge of space in U2 spy plane, covering every moment from the day-long training and meetings with the base staff to take-off and landing.